HORDB

ID: hor005257
Uniprot ID: P83225
Protein name: Natriuretic peptide TNP-a
Gene name: NA
Organism: Oxyuranus scutellatus scutellatus (Australian taipan) (Coastal taipan)
Family: natriuretic peptide family
Source: animal
Expression: Expressed by the venom gland.
Disease: NA
Comments: Does not activate natriuretic peptide receptor-A (NPR1).
Taxonomy: Oxyuranus scutellatus (species), Oxyuranus (genus), Acanthophiinae (subfamily), Elapidae (family), Colubroidea (superfamily), Serpentes (infraorder), Toxicofera, Episquamata, Unidentata, Bifurcata, Squamata (order), Lepidosauria (class), Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0090729 toxin activity
GO BP: GO:0007165 signal transduction; GO:0008217 regulation of blood pressure; GO:0035821 modulation of process of another organism; GO:0042311 vasodilation; GO:0097746 blood vessel diameter maintenance
GO CC: GO:0005576 extracellular region

Function: Exhibits vasoactive and hypotensive activity
Mechanism: Negative results: does not activate natriuretic peptide receptor-A (NPR1).
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P83225-F1.pdb

hor005257_AF2.pdb

hor005257_ESM.pdb

Mass:	425979	Formula:	C155H255N49O49S2
Absent amino acids:	AEMTWY	Common amino acids:	G
pI:	8.82	Basic residues:	6
Polar residues:	14	Hydrophobic residues:	8
Hydrophobicity:	-53.43	Boman Index:	-6587
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	72.29
Instability Index:	4735.71	Extinction Coefficient cystines:	125
Absorbance 280nm:	3.68

PubMed ID: 15652496
Title: Novel natriuretic peptides from the venom of the inland taipan (Oxyuranus microlepidotus): isolation, chemical and biological characterisation.